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Dapsone should not affect your ability to drive or operate machinery. Long term use may cause eye damage, if this happens you should talk to your doctor; see also section 4.

How to take Dapsone Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The tablets should be swallowed whole with some water. Use in Adults and Children over 12 years: Multibacillary also called MB or lepromatous leprosy: Paucibacillary also called PB or tuberculoid leprosy: Intensely itchy, blistering rash, called dermatitis herpetiformis: Pneumonia caused by a germ called Pneumocystis carinii: If you have a damaged liver, your doctor may give you a lower dose than for adults.

Ketoconazolul si eritromicina inhibitori ai CYP3A4 , pot inhiba metabolizarea tramadolului N- demetilarea , probabil si a metabolitului activ o-desmetiltramadolului. Nu a fost stabilita importanta clinica a acestor interactiuni. Pe perioada tratamentului cu tramadol nu se recomanda consumul bauturilor alcoolice, deoarece alcoolul etilic potenteaza efectul sedativ al opioidelor. Chinidina este un inhibitor al izoenzimei CYP2D6 P, reducand concentratia plasmatica a metabolitului M1 si micsorand concentratia plasmatica a tramadolului.

Fluoxetina, paroxetina si amitriptilina inhiba in mod asemanator metabolizarea tramadolului. Administrarea naloxonei in tratamentul supradozajului creste, de asemenea, riscul de convulsii. Se recomanda prudenta la bolnavii cu dureri abdominale acute nediagnosticate poate inlatura simptome esentiale pentru diagnostic.

Hipertensiunea intracraniana si traumatismele craniene impun multa prudenta, deoarece tramadolul poate masca anumite simptome importante pentru diagnostic si aprecierea evolutiei clinice. La pacientii varstnici sub 75 ani cu functie hepatica si renala normale nu este necesara reducerea dozei. Tramadolul se administreaza cu precautie la pacientii cu risc crescut de deprimare respiratorie.

Deoarece medicamentul contine tartrazina, parahidroxibenzoat de metil si parahidroxibenzoat de n- propil poate provoca reactii alergice chiar de tip intarziat. Administrarea concomitenta cu inhibitori de monoamioxidaza IMAO este contraindicata creste riscul sindromului serotoninergic. Asocierea cu hipnotice, sedative, anxiolitice, alte opioide analgezice sau antitusive si antihistaminice H1 sedative creste riscul deprimarii sistemului nervos central.

Administrarea concomitenta cu opioizi agonisti-antagonisti buprenorfina, nalbufina, pentazocina nu este recomandata, deoarece acestea scad efectul analgezic al tramadolului. Carbamazepina si alti inductori enzimatici cresc viteza de metabolizare a tramadolului, diminuand astfel intensitatea si durata efectului analgezic. Asocierea cu medicamente care scad pragul convulsivant neuroleptice, antidepresive, alte analgezice cu actiune centrala, anestezice locale creste riscul convulsiilor.

Studiile farmacocinetice au evidentiat ca administrarea concomitenta sau anterioara de cimetidina inhibitor enzimatic nu determina interactiuni semnificative clinic.

Ketoconazolul si eritromicina inhibitori ai CYP3A4 , pot inhiba metabolizarea tramadolului N- demetilarea , probabil si a metabolitului activ o-desmetiltramadolului. Nu a fost stabilita importanta clinica a acestor interactiuni. Pe perioada tratamentului cu tramadol nu se recomanda consumul bauturilor alcoolice, deoarece alcoolul etilic potenteaza efectul sedativ al opioidelor.

Taking tramadol during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use tramadol with alcohol, or with other drugs that cause drowsiness or slow your breathing. Seizures convulsions have occurred in some people taking this medicine.

Tramadol may be more likely to cause a seizure if you have a history of seizures or head injury, a metabolic disorder, or if you are taking certain medicines such as antidepressants, muscle relaxers, narcotic, or medicine for nausea and vomiting.

Tramadol can interact with many other drugs and cause dangerous side effects or death. Tell your doctor about all your current medicines and any you start or stop using. Do not crush the tramadol tablet. This medicine is for oral by mouth use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body.

Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death. Before taking this medicine You should not take tramadol if you are allergic to it, or if you have: Tramadol should not be given to a child younger than 12 years old. Do not give tramadol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking tramadol. Talk with your doctor about your seizure risk, which may be higher if you have ever had: Capsulele se administreaza cu suficient lichid , indiferent de aportul concomitent de alimente. Se recomanda administrarea dozei minime eficace. Actiune terapeutica Analgezice opioide. Contraindicatii - hipersensibilitate la tramadol sau la oricare dintre componentii produsului; Masuri de precautie Nu se recomanda utilizarea tramadolului ca substituent la persoanele dependente de morfina sau alte opioide , deoarece nu previne aparitia sindromului de abstinenta.

Desi riscul este mic, administrarea prelungita poate duce la aparitia dependentei fizice si psihice. La pacientii cu antecedente de dependenta medicamentoasa se recomanda administrarea tramadolului pe termen scurt si sub stricta supraveghere medicala.

Nu se recomanda utilizarea tramadolului ca substituent la persoanele dependente de morfina sau alte opioide , deoarece nu previne aparitia sindromului de abstinenta.

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